Following World War II, chelation therapy was used to treat workers who had painted United States naval vessels with lead-based paints.[17] In the 1950s, Norman Clarke, Sr. was treating workers at a battery factory for lead poisoning when he noticed that some of his patients had improved angina pectoris following chelation therapy.[18] Clarke subsequently administered chelation therapy to patients with angina pectoris and other occlusive vascular disease and published his findings in The American Journal of the Medical Sciences in December 1956.[19] He hypothesized that “EDTA could dissolve disease-causing plaques in the coronary systems of human beings.”[20] In a series of 283 patients treated by Clarke et al. From 1956-1960, 87% showed improvement in their symptomatology.[19] Other early medical investigators made similar observations of EDTA’s role in the treatment of cardiovascular disease (Bechtel, 1956; Bessman, 1957; Perry, 1961; Szekely, 1963; Wenig, 1958: and Wilder, 1962).
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