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The Moderna platform develops mRNA therapeutic candidates which are delivered in liposomes, using mRNA with modified uridine nucleosides to improve folding and translation efficiency, and mRNA drug candidates targeted to specific cell types.[11]
2020 vaccine development Edit
In January 2020, Moderna announced development of a vaccine to inhibit COVID-19 coronavirus, in competition with other biotechnology companies, such as Gilead Sciences, Vaxart, Inovio Pharmaceuticals, and Novavax.[12][13][14] The vaccine technology is a messenger RNA (mRNA) compound, named mRNA-1273, providing inhibition against SARS-CoV-2 that encodes for a form of the spike (S) protein on the virus.[15]
In March 2020, the Phase I human study of the vaccine candidate began in partnership with the US National Institute of Allergy and Infectious Diseases.[16] In April, the U.S. Biomedical Advanced Research and Development Authority (BARDA) allocated up to $483 million for Moderna’s vaccine development.[17] Plans for a Phase II dosing and efficacy trial to begin in May were approved by the FDA.[18] In preparation for manufacturing as many as a billion doses of the vaccine should it have proof of safety and efficacy in its human studies, Moderna signed a partnership with the Swiss vaccine producer, Lonza, who will begin batch manufacturing by July.[19]
GUESS WHO RUNS THE National Institute of Allergies and Diseases?
FAUCI