Loading ...Potent antiviral effect of silver nanoparticles on SARS-CoV-2.
Biochem Biophys Res Commun. 2020 11 26; 533(1):195-200.BB
Abstract
The pandemic of COVID-19 is spreading unchecked due to the
lack of effective antiviral measures. Silver nanoparticles (AgNP)
have been studied to possess antiviral properties and are presumed
to inhibit SARS-CoV-2. Due to the need for an effective agent
against SARS-CoV-2, we evaluated the antiviral effect of AgNPs.
We evaluated a plethora of AgNPs of different sizes and
concentration and observed that particles of diameter around 10
nm were effective in inhibiting extracellular SARS-CoV-2 at
concentrations ranging between 1 and 10 ppm while cytotoxic
effect was observed at concentrations of 20 ppm and above.
Luciferase-based pseudovirus entry assay revealed that AgNPs
potently inhibited viral entry step via disrupting viral integrity.
These results indicate that AgNPs are highly potent microbicides
against SARS-CoV-2
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