Loading ...I was looking into treating my Border Collie cross with Ivermectin and found out that many herding breeds have a gene mutation that makes it more dangerous for them to be treated with it. They can be tested for this mutation.
“Ivermectin Sensitivity in Collies and Similar Breeds
Neurotoxicity can also occur with Ivermectin usage in some dogs. This is particularly common in dogs that have a genetic mutation known as the MDR1 (multi-drug resistance) gene mutation.2
This gene mutation is known to occur most commonly in breeds such as collies, Australian shepherds, shelties, long-haired whippets, English sheepdogs, German shepherds, Silken Windhounds, Skye terriers, and other breeds with white feet. Symptoms of neurotoxicity include lack of coordination, muscle tremors, seizures, blindness, and death, thus earning the motto “white feet, do not treat” with Ivermectin.
Ivermectin used at dosages used for heartworm prevention is generally safe for these dogs. However, the drug should not be used at higher doses for dogs that may possess the MDR1 gene mutation. There is a test that can be performed to check for the gene mutation.”
https://www.thesprucepets.com/is-ivermectin-safe-dogs-and-cats-3384698